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PublicationsPublications

Correlation of the VFSS Esophageal Screen to High-Resolution Esophageal Manometry

29/03/2025

CONCLUSIONS: The esophageal screen as characterized by the MBSImP is not an effective predictor of esophageal function on HREM as defined by the CCv4.0. Future work may focus on a defining a standardized VFSS protocol for the esophageal screen and potentially a more nuanced assessment of esophageal findings on VFSS that may enhance the sensitivity of the modality to motility disorders.

Check the Impact of Mobile Health on Medication Adherence in Adolescents with Leukemia

29/03/2025

CONCLUSION: The use of a mobile health application enhances treatment adherence among adolescents with leukemia.

Treatment of chronic hepatitis C infection: strategies to address poor therapy adherence

29/03/2025

INTRODUCTION: Non-adherence to any therapy may be related to skipping drug doses, discontinuation of therapy, or loss of follow-up. It leads to the ineffectiveness of treatment, which is associated with obvious individual health losses, significant social and financial costs, and, in the case of infectious diseases, epidemiological consequences resulting from the possibility of further spread of infection.

A Rare Association of Celiac Disease and Aplastic Anemia

29/03/2025

Celiac disease (CD) is a chronic immune-mediated disorder triggered by the ingestion of gluten in genetically predisposed individuals. Association of CD and aplastic anemia (AA) has been reported in the literature, yet this association remains rare in children. The authors report a case of a previously healthy 4-year-old boy with 1-month history of diarrhea, asthenia, loss of appetite, and weight loss. Laboratory evaluation showed bicytopenia with very severe aregenerative anemia and...

Peroral plication of the esophagus as a treatment option for end-stage achalasia with sump formation

29/03/2025

CONCLUSIONS: POPE is a safe and repeatable long-term therapeutic option in end-stage achalasia.

Efficacy of mesenchymal stem cell-based therapies in the treatment of perianal fistulizing Crohn's disease: a systematic review and meta-analysis

29/03/2025

CONCLUSION: MSC-based therapies are effective for achieving combined remission of refractory and/or complex perianal fistulizing CD. The optimal efficacy effect is reached after 6 months of treatment. No superiority has yet been demonstrated between ASCs and BMSCs therapies.

Association of vitamin D and platelet-to-lymphocyte ratio in treatment escalation risk for newly diagnosed Crohn's disease adults

29/03/2025

CONCLUSION: This study underscores a significant interplay between VD levels and PLR in influencing treatment outcomes in CD. VDD exacerbates the risk of treatment escalation primarily in individuals with heightened PLR levels, highlighting the combined impact of vitamin D status and inflammation on disease progression of CD.

Heterogeneity of T cells regulates tumor immunity mediated by Helicobacter pylori infection in gastric cancer

29/03/2025

The impact of Helicobacter pylori (H. pylori) status on gastric cancer survival remains unclear. In this study, we conducted a prognostic analysis of 488 gastric cancer patients and performed single-cell RNA sequencing (scRNA-seq) on 18,717 T cells from six tumor samples with varying H. pylori statuses. Our findings revealed that gastric cancer patients with H. pylori infection had significantly longer survival times compared to those with negative H. pylori status. After unsupervised...

Lipopolysaccharide-binding protein (LBP): a prognostic biomarker for gastric cancer linked to immune infiltration

29/03/2025

CONCLUSION: LBP is intricately linked to gastric cancer pathogenesis; it influences cell proliferation, migration, and invasion, thereby representing a valuable prognostic and diagnostic biomarker. This study not only highlights the potential of LBP as a therapeutic target but also provides the groundwork for future investigations into its mechanistic pathways in gastric cancer.

Early diagnosis of Crohn's disease in patients presenting with a perianal fistula: systematic review and development of a perianal red flags index

29/03/2025

CONCLUSIONS: The perianal red flags index has a good predictive value for early identification of patients with PAF at risk for underlying CD.

A comparison of three kinds of balloon dilatations for patients with benign esophageal strictures

29/03/2025

Benign esophageal strictures (BES) have been usually treated with balloon dilatation with occasionally drug-coated balloon (DCB) or large balloon dilatation. We compared the clinical outcomes of 3 types of dilatations: small balloon dilatation, DCB dilatation, and large balloon dilatation for the treatment of BES. This retrospective study evaluated 3 groups of 82 consecutive patients with BES who underwent dilatation of either small balloon (Group S, n = 25), DCB (Group D, n = 22) or large...

Discrepancies in perceptions of well-being: comparing parental and pediatric PROMIS-patient-reported outcomes in Crohn's disease

29/03/2025

CONCLUSION: This study highlights the importance of integrating patient and parental perspectives in the clinical management of pediatric CD. The observed discrepancies in disease-related perceptions, influenced by parental educational and professional background, underscore the need for comprehensive assessments to ensure accurate, patient-centered care. For broader generalization, further research should explore these dynamics in newly diagnosed and hospitalized patients.

Villous atrophy in celiac disease: striking differences in endoscopic findings between the duodenal bulb and descending duodenum

29/03/2025

A woman in her 40 s was diagnosed with celiac disease after a decade-long history of abdominal pain and abnormal bowel movements. We compared villous atrophy in the duodenal bulb (DB) and descending duodenum (DD) using endoscopic and histopathological findings. Endoscopy revealed villous loss, a fine granular pattern, and groove-like depressions in the DD that were clearly visualized under narrow-band imaging (NBI) magnification. Histopathological examination revealed villous loss, crypt...

Therapeutic treatment of hepatitis E virus infection in pigs with a neutralizing monoclonal antibody

29/03/2025

Hepatitis E virus (HEV) poses a significant risk to human health. In Europe, the majority of HEV infection are caused by the zoonotic genotype 3 (HEV-3), which can cause chronic hepatitis E in immunocompromised patients and those with pre-existing liver disease, and may eventually develop into fatal liver cirrhosis. In this study, we examined the effectiveness of a monoclonal antibody (MAb) treatment strategy using a well established HEV-3 pig model with intravenous infection. For this purpose,...

Machine Learning Models predicting Decompensation in Cirrhosis

28/03/2025

CONCLUSIONS: Laboratory parameters, genetic variants and infections can help to predict the risk of cirrhosis decompensation. This proof-of-concept study adds data for the future development of advanced models to identify patients at risk.

Leukocytoclastic vasculitis as a rare adverse effect of ustekinumab in a patient with Crohn's disease

28/03/2025

No abstract

Colovenous Fistula?

28/03/2025

No abstract

A Case of Verrucous Esophageal Carcinoma with Submucosal Invasion Resected by Endoscopic Submucosal Dissection after Long-term Observation

28/03/2025

No abstract

Shifting trends of liver cirrhosis: causes, complications and future outlook

28/03/2025

No abstract

Colitis Trouble up High: A Case of Gastroduodenal Ulcerative Colitis and Literature Review

28/03/2025

CONCLUSION: This review sheds light on a rare presentation of UC. This highlights the need for further research into the pathogenesis of UC and treatment strategies for patients presenting with UGI UC. Our case further strengthens the use of anti-TNFɑ, particularly adalimumab for UGI UC and highlights the need for further research into the pathogenesis of inflammatory bowel disease.
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