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PublicationsPublications

A low-cost pediatric gastrostomy securement system for resource-limited settings: a preliminary observational study

19/04/2025

CONCLUSION: The device shows potential as an effective pediatric gastrostomy solution for low-resource settings; it is functional, safe, and easy to use, but requires improvements in durability and ease of installation, which will be addressed in future advancements.

Obeticholic Acid vs Fibrates as Second-Line Therapy for Primary Biliary Cholangitis: Systematic Review and Meta-Analysis

19/04/2025

CONCLUSION: In patients with PBC and an incomplete response to UDCA, fibrates seem to be associated with greater ALP reduction and achievement of response criteria compared to OCA.

SPECTREPlex: an automated, fast, high-resolution enabled approach for multiplexed cyclic imaging and tissue spatial analysis

19/04/2025

Mapping the spatial organization of tissues is critical to understanding organ biology in health and disease. Developments in multiplexed antibody-based, fluorescence labelling methods have provided unique insights into tissue microenvironments. However, many current methods have a variety of limitations that reduce their practical utilization including cost, time and technical complexity. To address these drawbacks, we developed Spatial Photo-inactivation Enhanced Cyclic Target REsolved...

Diagnostic accuracy of liver stiffness measurement for the diagnosis of veno-occlusive disease/sinusoidal obstruction syndrome after hematopoietic stem cell transplantation (HSCT), the ELASTOVOD STUDY: an investigator-initiated, prospective, multicentre diagnostic clinical trial

19/04/2025

Hepatic Veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS) is a severe complication following hematopoietic stem cell transplantation (HSCT), traditionally diagnosed based on clinical criteria. This study aimed to evaluate the diagnostic performance of liver stiffness measurement (LSM) as a non-invasive tool for non invasive diagnosis of VOD/SOS. A multicentre clinical trial was conducted in Italy from April 2018 to December 2021, screening 1089 patients across 25 centers. VOD/SOS...

ARL6IP5 in cancers: bidirectional function and therapeutic value

19/04/2025

ARL6IP5 (ADP-ribosylation-like factor 6 interacting protein 5) plays an important role in a variety of physiological or pathological processes, including in cancers. However, the biological roles of ARL6IP5 in cancers are controversial. In this mini-review, we summarized the current understanding on the role of ARL6IP5 in cancers, particularly in the progression of chronic hepatitis virus-related hepatocellular carcinoma, as well as the potential values of ARL6IP5 in cancer therapy.

Prevalence and coexistence of locomotive syndrome with reduced mobility and metabolic syndrome: a cross-sectional study of 35,059 Japanese adults

19/04/2025

Metabolic syndrome (MetS), marked by visceral obesity, hypertension, hyperglycemia, and dyslipidemia, elevates cardiovascular risk. Locomotive syndrome (LS), characterized by age-related mobility decline, often precedes frailty and sarcopenia. We investigated the prevalence and association between MetS and LS among Japanese middle-aged and older adults. This retrospective cross-sectional study was conducted using clinical records of 35,059 Japanese adults who underwent health check-ups between...

Microbiome data management in action workshop: Atlanta, GA, USA, June 12-13, 2024

19/04/2025

Microbiome research is revolutionizing human and environmental health, but the value and reuse of microbiome data are significantly hampered by the limited development and adoption of data standards. While several ongoing efforts are aimed at improving microbiome data management, significant gaps still remain in terms of defining and promoting adoption of consensus standards for these datasets. The Strengthening the Organization and Reporting of Microbiome Studies (STORMS) guidelines for human...

Transcription factor JUNB is required for transformation of EpCAM-positive hepatocellular carcinoma (HCC) cells into CD90-positive HCC cells in vitro

19/04/2025

Hepatocellular carcinoma (HCC) harbors two types of stem cells-epithelial and mesenchymal stem cells. The mechanism by which epithelial EpCAM-positive HCC cells transform into mesenchymal CD90-positive HCC cells remains unclear. On peritumoral fibrotic nodules, epithelial HCC cells form communities with stromal cells, driving tumor growth and malignancy. We aimed to clarify the mechanism by which epithelial cell adhesion molecule (EpCAM)-positive HCC cells contribute to the phenotype of...

Assessment of the impact of power business intelligence on adenoma detection rate: a prospective observational trial

19/04/2025

CONCLUSIONS: The use of Power BI was not associated with a higher ADR at a high-performing institution but may benefit low-performing endoscopists. Efforts should target behavioral changes in modifiable technical factors to drive meaningful ADR improvements.

Insights into the blood, gut, and oral microbiomes in Chinese patients with myocardial infarction: a case-control study

19/04/2025

CONCLUSION: This study demonstrates significant alterations in the blood, gut, and oral microbiome profiles of MI patients, identifying specific bacterial taxa strongly associated with key markers of myocardial infarction. The unique microbial patterns detected in the blood provide compelling evidence for the existence of a stable core blood microbiome, highlighting its importance as a key contributor to cardiovascular health and disease progression.

Evaluating the effectiveness of mandala coloring on post-operative anxiety in mothers of children undergoing congenital anomaly surgery: A randomized controlled clinical trial

19/04/2025

CONCLUSION: Mandala coloring appears to be an effective intervention for reducing anxiety level in mothers of children undergoing surgery for congenital abnormalities. The study suggests that therapeutic art activities can improve psychological well-being post-operatively, urging further research to explore their long-term effects.

Risk of colon polyps and colorectal cancer in primary biliary cholangitis, a population-based retrospective cohort study in Taiwan

19/04/2025

CONCLUSIONS: This population-based retrospective cohort study identified a 1.68-fold increased risk of colon polyps and CRC in patients with PBC, suggesting a potential association with colonic neoplasia. Further research is warranted to evaluate the role of endoscopic surveillance in patients with PBC.

Characteristics of clinical studies on chronic pancreatitis registered in ClinicalTrials.gov - A cross-sectional analysis

19/04/2025

No abstract

Letter to the Editor regarding "Concomitant virus infection increases mortality and worsens outcome of acute pancreatitis: A systematic review and meta-analysis"

19/04/2025

No abstract

Risk factors for residual tumors in histologically incompletely resected rectal neuroendocrine tumors

19/04/2025

CONCLUSION: Salvage resection should be considered for R1/Rx-resected r-NET cases with risk factors for residual tumors to lower the likelihood of recurrence.

Oleanolic acid inhibits M2 macrophage polarization and potentiates anti-PD-1 therapy in hepatocellular carcinoma by targeting miR-130b-3p-PTEN-PI3K-Akt signaling and glycolysis

18/04/2025

CONCLUSION: Our findings uncover a new mechanism of hypoxic HCC cells-induced M2 polarization of macrophages through exosomal miR-130b-3p-PTEN-PI3K-Akt signaling. The combination therapy of OA with anti-PD1 antibody may lead to substantial improvements of the immunotherapy efficacy and expand the beneficiaries.

SLC7A11 in Fibrosis: Molecular Mechanisms and Future Prospects

18/04/2025

Solute carrier family 7 member 11 (SLC7A11), or xCT, is a cystine-glutamate antiporter crucial for maintaining cellular antioxidant capacity through the uptake of cystine, which is vital for glutathione synthesis. This protein plays an important role in regulating ferroptosis, an iron-dependent form of cell death. Fibrosis, a pathological condition characterized by the excessive accumulation of fibrous connective tissue, is a health challenge because it can lead to organ dysfunction and failure....

Exploring the Prognostic and Predictive Impact of Genomic Loss of Heterozygosity and Homologous Recombination Deficiency Alterations in Patients With Metastatic Colorectal Cancer

18/04/2025

CONCLUSION: In pMMR/MSS mCRC, gLOH-high was associated with worse prognosis and higher benefit from the addition of anti-PD-L1 agents to chemotherapy. If confirmed in larger series, these results may inform the design of clinical trials.

Cancer Incidence in Kabul, Afghanistan: The First Report From the Population-Based Cancer Registry

18/04/2025

CONCLUSIONS: The high incidence of breast, stomach, and esophagus cancers highlights the need for policymakers and healthcare providers to develop cancer control programs focused on primary prevention, early detection, and quality diagnosis and treatment. Additionally, this study underscores the importance of cancer registries and emphasizes the need to strengthen the KCR to improve data quality.

HIV and Non-HIV Patients Have Similar Rates of Neoplastic Findings on Screening Colonoscopy Within a Predominantly African American Cohort

18/04/2025

INTRODUCTION: With the reduction in human immunodeficiency virus (HIV)-related mortality secondary to antiretroviral therapy, chronic medical conditions and age-related cancers account for a larger proportion of mortality among those with HIV. Cancer risk overall remains elevated in HIV patients, and cancer screening data in this population is limited. The primary study aim was to determine whether screening colonoscopy findings differed between HIV and non-HIV patients.
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