Describe the IL23/IL17 axis

In this video, Erica Heagy, NP, from Alaska Digestive and Liver Disease, discusses the IL-23/IL-17 axis and its role in inflammatory bowel disease (IBD) and other immune-mediated conditions. Learn how the IL-23 cytokine promotes differentiation of CD4+ T cells into Th17 cells, stimulating the production of IL-17A, IL-17F, TNF, and IL-6. This pathway is critical in diseases like psoriasis, Crohn's disease, ulcerative colitis, psoriatic arthritis, and axial spondyloarthritis. Targeting IL-23 or IL-17 represents a promising therapeutic approach for these conditions.